
Marksman · physical (AD) damage
Vayne is a Marksman that deals physical (AD) damage and brings airborne, stun. Some of their lockdown (airborne) ignores tenacity, so you dodge it; you can't cleanse or Merc' through it. Below is Vayne's highest-win-rate build from high-elo games; open the counter-build tool to tune it against your specific enemy team.

Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.

Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage.

Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.

Readying herself for an epic confrontation, Vayne gains increased Attack Damage, Invisibility during Tumble, reduced Tumble cooldown, and more bonus Move Speed from Night Hunter
E CondemnStuntenacity helpsFROM
E CondemnHover a crowd-control type to see which ability it comes from.
Precision
Press the Attack
Lethal Tempo
Fleet Footwork
Conqueror
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
Resolve
Grasp of the Undying
Aftershock
Guardian
Demolish
Font of Life
Shield Bash
Conditioning
Second Wind
Bone Plating
Overgrowth
Revitalize
Unflinching

Based on 8470 games · 49.1% win rate · challenger+grandmaster+master+emerald-diamond+platinum-emerald · patch 16.18.1.
Precision
Press the Attack
Lethal Tempo
Fleet Footwork
Conqueror
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
Resolve
Grasp of the Undying
Aftershock
Guardian
Demolish
Font of Life
Shield Bash
Conditioning
Second Wind
Bone Plating
Overgrowth
Revitalize
Unflinching

Based on 4420 games · 49.8% win rate · challenger+grandmaster+master+emerald-diamond+platinum-emerald · patch 16.18.1.
Precision
Press the Attack
Lethal Tempo
Fleet Footwork
Conqueror
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
Sorcery
Summon Aery
Arcane Comet
Deathfire Touch
Axiom Arcanist
Manaflow Band
Nimbus Cloak
Transcendence
Celerity
Absolute Focus
Scorch
Waterwalking
Gathering Storm

Based on 257 games · 50.6% win rate · challenger+grandmaster+master+emerald-diamond+platinum-emerald · patch 16.18.1.
Precision
Press the Attack
Lethal Tempo
Fleet Footwork
Conqueror
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
Resolve
Grasp of the Undying
Aftershock
Guardian
Demolish
Font of Life
Shield Bash
Conditioning
Second Wind
Bone Plating
Overgrowth
Revitalize
Unflinching

Based on 152 games · 39.5% win rate · challenger+grandmaster+master+emerald-diamond+platinum-emerald · patch 16.18.1.